Cheap Flights from Buffalo Niagara to Panama City

Compare Buffalo Niagara to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

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Flight deals from Buffalo Niagara Airport to Panama City

Looking for a cheap last-minute deal or the best return flight from Buffalo Niagara Airport to Panama City? If you want to travel next month, return fares start from ج.م.‏ 34,994. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Buffalo Niagara to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Buffalo Niagara to Panama City flights are currently cheapest in May.

Alternative Buffalo Niagara to Panama City routes

Looking for the cheapest, fastest or easiest route from Buffalo Niagara to Panama City? You could fly into the following airports instead.

Buffalo to Panama City: Flight information

The things to know before you go.
Cheapest flight foundج.م.‏ 14,299
Cheapest month to flyMay

Finding cheap flights from Buffalo Niagara to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Buffalo Niagara to Panama City is ج.م.‏ 34,755. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Buffalo Niagara to Panama City. But we found flights with one or more stops from ج.م.‏ 34,755.
As of April 2026, there are no flights flying from Buffalo Niagara to Panama City.
The cheapest month to fly from Buffalo Niagara to Panama City is usually April.
If you're flying from Buffalo Niagara Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from ج.م.‏ 34,755.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Buffalo Niagara Airport to Panama City on Wednesday, 15 April 2026.
No airlines currently offer direct flights between Buffalo Niagara Airport and Panama City. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In April, the average temperature is usually around 28°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
Currently, Frontier Airlines offers the cheapest flight tickets to Panama City.

Flying from Buffalo Niagara International Airport (BUF) to Panama City: what you need to know

  • Panama City's timezone is UTC-5, which is the same as Buffalo (the location of Buffalo Niagara International Airport).

  • Leave plenty of time to catch your BUF to Panama City flight. A good rule of thumb is to arrive at least two hours before international departures and an hour ahead for domestic flights.

  • Be prepared for bigger queues during popular months such as August. Arriving up to four hours ahead of an international flight and two hours for domestic departures is a wise move.

  • A stopover is the perfect opportunity to break up your trip and possibly even explore a different city. When browsing for plane tickets from BUF to Panama City, deselect the 'Direct flights only' box to see where you can visit along the way. Here are some options to consider:

    • Atlanta Hartsfield-Jackson International Airport (ATL)

    • Miami International Airport (MIA)

    • Orlando International Airport (MCO)

  • Located around 13 kilometres from the centre of Buffalo, BUF can be reached in about 20 minutes by car. The journey on public transport takes roughly 40 minutes.

  • Want a stress-free start to your trip? Stay near BUF. Whether you have an early flight from Buffalo Niagara International Airport to Panama City or want to avoid feeling rushed, these hotels are a convenient choice:

  • 74% of flights taking off from Buffalo Niagara International Airport touch down at their destination on schedule.

  • The address for BUF is Genesee Street.

How to find the cheapest flights from Buffalo Niagara International Airport (BUF) to Panama City

  • The lowest price we've seen for a one-way Buffalo Niagara International Airport to Panama City flight is ج.م.‏ 14,299. The cheapest price for a return flight is ج.م.‏ 34,755. Bear in mind fares may change due to demand at the time of booking.

  • Don't leave things to the last minute. You're more likely to find cheap flights from BUF to Panama City if you book ahead. Airlines often have some excellent early bird rates.

  • Finding cheap tickets from Buffalo Niagara International Airport to Panama City is easier if you're flexible with your trip dates. Use the 'Whole month' function to access the lowest prices across each month and walk away with an awesome deal.

  • Spend less time searching for cheap flights from BUF to Panama City by creating a Price Alert. You'll receive an email or push notification on the app when a special offer becomes available.

  • Save on your flight from Buffalo Niagara International Airport to Panama City with the help of our filters. Choose your preferred duration, departure time and airlines, then sort the results by 'Cheapest' for the best deals.

Airports in Panama City

Panama City Tocumen International Airport (PTY)

  • The distance from Panama City Tocumen International Airport (PTY) to central Panama City is roughly 24 kilometres. It'll take you around 35 minutes to get to the centre driving.

  • It'll take around 50 minutes to get there using public transport.

  • The last thing you want is a lengthy journey to your hotel if you're getting in late on a flight from Buffalo Niagara International Airport to Panama City. Stay at one of these accommodation options near PTY instead:

  • To secure the lowest price, book your ride from Panama City Tocumen International Airport around three weeks ahead of your flight from BUF to Panama City.

Panama Pacifico International Airport (BLB)

  • Central Panama City is around 6 kilometres from Panama Pacifico International Airport (BLB). After your flight from Buffalo Niagara International Airport to Panama City has touched down and you've made your way out of the airport, expect a drive of about 10 minutes.

  • If you travel by public transport, the journey will take you 20 minutes or so.

  • Place the 'Do not disturb' sign on your door and unwind at a hotel close to BLB. Here are a few options where you can check in after your BUF to Panama City flight:

  • Avoid last-minute price surges. Reserving your ride one week before your arrival at BLB will save you money.

Best time to go to Panama City

  • September is the quietest month for flights from Buffalo Niagara International Airport to Panama City, while January is the busiest. Work out the best time to visit Panama City based on whether you prefer a laid-back vibe or a lively atmosphere.

  • Before locking in your Buffalo Niagara International Airport to Panama City plane ticket, think about what kind of weather you prefer. March is the warmest month in Panama City, with temperatures ranging from 21ºC to 32ºC.

  • Search for cheap tickets from BUF to Panama City in January if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between 22ºC and 31ºC on average.

More about Panama City

  • Once you've booked your flight from Buffalo Niagara International Airport to Panama City, choose a hotel that combines comfort with a great location. Make one of these options your base for exploring Panama City:

  • There are so many things to see and do in this city it can be tricky to know where to begin. Metropolitan Cathedral (Catedral Metropolitan), Casco Viejo and Independence Square are top sights which should be on any good Panama City itinerary.

Explore more of Panama

  • Panama City has its own special appeal, but there are so many other parts of Panama you'll want to see. About 322 kilometres west of Panama City, a trip to David will keep your itinerary busy. Don't miss top attractions like Museo Antropológico y Etnográfico Dr. Roberto De La Guardia, Raptors To The Rescue and Unachi Botanical garden.

  • Time for another stop? Make your way to Santiago de Veraguas. It's roughly 193 kilometres southwest of Panama City and boasts highlights like Santiago the Apostle Cathedral, Santiago de Veraguas.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.