Cheap Flights from Des Moines to Knoxville

Compare Des Moines to Knoxville flight deals

Find the cheapest month or even day of the year to fly to Knoxville

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Find the cheapest month to fly from Des Moines to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Knoxville flights are currently cheapest in September.

Des Moines to Knoxville: Alternative routes

Compare routes from Des Moines to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

Des Moines to Knoxville: Flight information

The things to know before you go.
Cheapest flight foundج.م.‏ 4,542
Cheapest month to flySeptember

Finding cheap flights from Des Moines to Knoxville: Frequently asked questions

The best price we found for a return flight from Des Moines to Knoxville is ج.م.‏ 10,282. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Des Moines to Knoxville. But we found flights with one or more stops from ج.م.‏ 10,282.
As of August 2025, there are no flights flying from Des Moines to Knoxville.
The cheapest month to fly from Des Moines to Knoxville is usually November.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Knoxville Airport on Sunday, 2 November 2025.
No airlines currently offer direct flights between Des Moines Airport and Knoxville Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Allegiant Air offers the cheapest flight tickets to Knoxville.

Travelling from Des Moines International Airport (DSM) to McGhee Tyson Airport (TYS): what you need to know

  • Arrive at the airport on time so you don't miss your DSM to TYS flight. Be there at least two hours ahead for international flights and an hour early for domestic departures to avoid any last-minute rush.

  • During popular months such as July, it's best to get to the airport well in advance. Plan to arrive two hours before domestic departures and four hours ahead for international flights when you travel during peak periods in general.

  • We make it a piece of cake to book a flight with a stopover. To see all your options for tickets from Des Moines International Airport to McGhee Tyson Airport, uncheck 'Direct flights only.' Then, choose a flight with a stop long enough to tour the city of your choice. Stopovers between DSM and TYS include:

    • O'Hare International Airport

    • Charlotte Douglas International Airport

    • Hartsfield-Jackson Atlanta International Airport

How to find the cheapest flights from Des Moines International Airport (DSM) to McGhee Tyson Airport (TYS)

  • The lowest price we've seen for a one-way Des Moines International Airport to McGhee Tyson Airport flight is ج.م.‏ 4,542. A round-trip plane ticket right now is ج.م.‏ 10,282. Depending on the availability and when you book, these fares may change.

  • Don't wait until the last moment. You're more likely to get cheap tickets from DSM to TYS if you book early. Airlines often have some excellent early bird rates.

  • If you can be flexible with your trip dates, use the 'Whole month' search tool. It'll find the cheapest price in every month when looking for your flight from Des Moines International Airport to McGhee Tyson Airport.

  • Cut down on the time spent looking for cheap flights from DSM to TYS by setting up a Price Alert. We'll send you an email or notification through the app when a special offer becomes available.

  • Tailor your flights with filters. Pick your preferred arrival and departure times, total journey duration and airlines. You can also sort your results by 'Fastest,' 'Cheapest' or 'Best' flights from Des Moines International Airport to McGhee Tyson Airport.

Handy information about Des Moines International Airport (DSM)

  • DSM is located at 5800 Fleur Drive, Suite 201.

  • Des Moines International Airport has an excellent on-time performance, making delays less likely. Departures from DSM arrive at their destination as scheduled 80.45% of the time.

  • To get to Des Moines International Airport from central Des Moines, it takes about 15 minutes if you're planning to drive. This depends on traffic, however. It's approximately 10 kilometres from the airport to the city centre.

  • Catching public transport? Expect a trip time of around 45 minutes.

  • Have an early flight from Des Moines International Airport to McGhee Tyson Airport? Avoid the stress of rushing to the terminal (and sneak in some extra precious sleep) by choosing one of these hotels near DSM:

Arriving at McGhee Tyson Airport (TYS)

  • If you're landing on a late Des Moines International Airport to McGhee Tyson Airport flight, nothing beats the convenience of staying near the terminal. Collect your bags from the carousel and then be showered and snoozing soon after at one of these accommodation options near TYS:

  • Say yes to new adventures by picking up a McGhee Tyson Airport rental car. Grab your wheels from Budget, Alamo or Avis and explore beyond Knoxville's usual tourist stops.

  • Booking your vehicle from McGhee Tyson Airport around three weeks ahead gives you the best shot at securing a great deal.

Getting from McGhee Tyson Airport (TYS) to central Knoxville

  • TYS is located at 2055 Alcoa Highway.

  • McGhee Tyson Airport to central Knoxville has a drive time of about 20 minutes. It's approximately 23 kilometres away.

When to fly to McGhee Tyson Airport (TYS)

  • The quietest month for a flight from Des Moines International Airport to McGhee Tyson Airport is February, while July is the busiest. Choose the best time to go to Knoxville based on whether you prefer a faster pace or a more relaxed vibe.

  • When booking your flight from Des Moines International Airport to McGhee Tyson Airport, think about the kind of weather you enjoy. July is the warmest month in Knoxville, with the temperature ranging from 17ºC to 32ºC.

  • Search for cheap tickets from DSM to TYS in January if you like cooler conditions. Temperatures are at their lowest around then, ranging between -6ºC and 11ºC on average.

Explore more of United States

  • Columbus is just one of the many places in United States waiting to be discovered once you've taken in the sights of Knoxville. Around 451 kilometres away to the north, its top attractions include Franklin Park Conservatory and Botanical Gardens, Ohio Statehouse and German Village.

  • Around 467 kilometres north-west of Knoxville, Indianapolis is another favourite stop in United States. Start your sightseeing at The Children's Museum of Indianapolis, Indianapolis Museum of Art and Indianapolis Zoo.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.