Cheap Flights from Knoxville to San Francisco International

Compare Knoxville to San Francisco International flight deals

Find the cheapest month or even day of the year to fly to San Francisco International

Book the best San Francisco International fare with no extra fees

Flight deals from Knoxville to San Francisco International

Looking for a cheap last-minute deal or the best return flight from Knoxville to San Francisco International? Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Knoxville to San Francisco International

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to San Francisco International flights are currently cheapest in January.

Knoxville to San Francisco International: Alternative routes

Compare routes from Knoxville to San Francisco below. You may find an airport to fly into that's cheaper, faster, or easier than San Francisco International.

Knoxville to San Francisco: Flight information

The things to know before you go.
Cheapest flight foundج.م.‏ 5,819
Cheapest month to flyJanuary

Finding cheap flights from Knoxville to San Francisco International: Frequently asked questions

The best price we found for a return flight from Knoxville to San Francisco International is ج.م.‏ 10,899. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Knoxville to San Francisco International. But we found flights with one or more stops from ج.م.‏ 10,899.
As of October 2025, there are no flights flying from Knoxville to San Francisco International.
The cheapest month to fly from Knoxville to San Francisco International is usually December.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to San Francisco International Airport on Monday, 8 December 2025.
No airlines currently offer direct flights between Knoxville Airport and San Francisco International Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to San Francisco International but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to San Francisco is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Frontier Airlines offers the cheapest flight tickets to San Francisco International.

Flying from McGhee Tyson Airport (TYS) to San Francisco International Airport (SFO): what you need to know

  • San Francisco is three hours behind Knoxville and observes the UTC-7 timezone.

  • Give yourself plenty of time to catch your TYS to SFO flight. As a rule of thumb, arrive two hours before international departures and an hour ahead for domestic flights.

  • You can expect longer queues in popular months like July. Arriving up to four hours in advance for international flights and two hours for a domestic departure is a good idea.

How to find the cheapest flights from McGhee Tyson Airport (TYS) to San Francisco International Airport (SFO)

  • ج.م.‏ 5,819 is the lowest price for a one-way McGhee Tyson Airport to San Francisco International Airport flight. A return flight starts at ج.م.‏ 10,899. These fares can change based on demand and availability.

  • It's often best to book early if you're hoping to get cheap tickets from TYS to SFO. That's because airlines change prices based on demand, which tends to increase closer to the date of departure.

  • If you can be flexible with your trip dates, try using the 'Whole month' search tool. It'll show you the cheapest price across every month when looking for a flight from McGhee Tyson Airport to San Francisco International Airport.

  • Spend less time searching for cheap flights from TYS to SFO by setting up a Price Alert. You'll receive an email or notification on the app when a new low fare is offered.

  • Pick your preferred arrival and departure times, number of stops and airlines with the filters. Or sort your results by 'Cheapest' to see the best deals on flights from McGhee Tyson Airport to San Francisco International Airport.

Handy information about McGhee Tyson Airport (TYS)

  • The address for TYS is 2055 Alcoa Highway.

  • 78.98% of flights leaving from McGhee Tyson Airport make it to their destination on schedule.

  • Central Knoxville to McGhee Tyson Airport is approximately 23 kilometres. Depending on traffic, it'll take about 20 minutes to get there if you're ride-sharing, catching a cab or driving.

  • Need a handy hotel close to TYS? If you're boarding an early flight from McGhee Tyson Airport to San Francisco International Airport, these accommodation options will have you moments from check-in:

Arriving at San Francisco International Airport (SFO)

Getting from San Francisco International Airport (SFO) to central San Francisco

  • San Francisco International Airport is roughly 21 kilometres from central San Francisco. Driving there takes about 20 minutes.

  • If you're travelling by public transport, expect a journey of around 45 minutes.

When to fly to San Francisco International Airport (SFO)

  • August is the busiest month for flights from McGhee Tyson Airport to San Francisco International Airport. To escape the crowds, travel to San Francisco in February.

  • Lock in your flight from McGhee Tyson Airport to San Francisco International Airport for September if you want to explore San Francisco during its warmest month. You can expect temperatures of between 12ºC and 22ºC.

  • If you want cooler conditions, search for a cheap ticket from TYS to SFO in January. Average temperatures are between 6ºC and 16ºC then.

Explore more of United States

  • San Francisco has plenty to offer, but there are so many other parts of United States waiting to be discovered. About 64 kilometres south-east of San Francisco, a trip to San Jose will keep your itinerary packed. Don't miss top attractions like Winchester Mystery House, Rosicrucian Egyptian Museum and San Jose Museum of Art.

  • Fresno is another standout destination in United States and is around 257 kilometres south-east of San Francisco. No trip is complete without dropping by Forestiere Underground Gardens, Fresno Chaffee Zoo and Shinzen Japanese Garden.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.